Multiple Askbots or Category Assigned Posts and Moderators?

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I am exploring ways to customize the structure of Askbot questions and moderation permissions.

Any insight on the best way to approach the following requirements?

1. Questions require assignment to single top level predefined Categories.
2. Special moderators are assigned to specific categories.

Not sure what the most straightforward path is here. Multiple AskBot instances (vs categories) with a single user system, or is there a way to customize a single Askbot instance to perform with these requirements?